Wound, Ostomy and Continence Nurses Society (WOCN) Practice Exam

What type of medication is known to potentially negatively impact wound healing?

1. Beta-blockers

2. Corticosteroids

3. Antibiotics

4. Antihistamines

The correct answer is: Corticosteroids

Corticosteroids are known to potentially negatively impact wound healing due to their immunosuppressive effects and the way they alter inflammatory responses. These medications can inhibit the proliferation of fibroblasts, which are essential for wound healing, and can also reduce collagen synthesis. The anti-inflammatory properties of corticosteroids, while beneficial in managing inflammation, can result in a reduced inflammatory response necessary for the early phases of healing. In contrast, beta-blockers, while they might have some effects on circulation and blood flow, are less directly associated with negative impacts on wound healing than corticosteroids. Antibiotics primarily aim to prevent or treat infections, which can actually support wound healing rather than hinder it. Antihistamines are primarily used to manage allergic reactions and symptoms but are not generally associated with a direct adverse effect on wound healing. Therefore, corticosteroids stand out as the medication most likely to impair the complex biological processes involved in effective wound healing.